Program

Below is our current program.

All talk will be held at MERF 1110A.

Max poster size is: 4 feet long and 6 feet wide

Arrival

6:00 pm Faculty Dinner

7:30am – 8:30am Breakfast; setting up posters

8:30am – 10:30am Session 1: Replication stress and genome instability

Discussion Leader: Anna Malkova, University of Iowa.

8:30am – 9:30am Keynote talk: Sharon Cantor, University of Massachusetts Medical School. Redefining Chemotherapy response and BRCAness.
9:30am – 9:45am Alice Meroni, Washington University in St. Louis. NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors.
9:45am – 10:00am Arvind Panday, Harvard Medical School. Synthetic lethality and repair protein dynamics in mammalian stalled fork repair.
10:00am – 10:15am Sarah McMillan, Department of Biomolecular Chemistry, University of Wisconsin-Madison, Wisconsin. Structural insights into replicative DNA helicase reloading in DNA replication restart.
10:15am – 10:30am Ena Haseljic, Department of Medicine, Washington University in St. Louis. Nucleolytic processing of the abasic site represents an effective approach for augmenting PARP inhibitor responses.

10:30am – 11:00am Coffee break

11:00am – 12:00pm Vendor presentations:

12:00pm – 1:00pm Lunch

1:00pm – 2:00pm Poster session I: Odd numbers

2:00am – 4:00am Session 2: DNA repair and chromosomal organization

Discussion Leader: Sarit Smolikove, University of Iowa.

2:00pm – 3:00pm Keynote talk: Douglas Koshland, University of California, Berkeley. The unsolved mysteries of cohesin-mediated chromosome structure.
3:00pm – 3:15pm Neha Chetlangia, University of Illinois Urbana Champaign. ORCA/LRWD1 organizes 3D genome architecture through polycomb repressive complex.
3:15pm – 3:30pm Xinran Geng, Department of Pharmacology, Case Western Reserve University. 53BP1 regulates heterochromatin through Liquid-Liquid Phase Separation.
3:30pm – 3:45pm Benjamin Ryan, University of Kansas Medical Center. Structural basis if DNA synthesis in Nucleosome by DNA Polymerase Beta. University of Kansas.
3:45pm – 4:00pm Matthew Botchman, Molecular & Cellular Biochemistry Department, Indiana University, Cdc13 exhibits dynamic binding to telomeric DNA.

4:00pm – 5:00pm Poster session II (with refreshments): Even numbers

5:00am – 6:00am Session 3: DNA repair and mutagenesis

Discussion Leader: Marc Wold, University of Iowa.

5:00pm – 5:15pm Polina V. Shcherbakova, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.
5:30pm – 5:45pm Zachary Kockler, Genomic Integrity & Structural Biology Laboratory, National Institute of Environmental Health Sciences. Hypermutation of chromosomal DNA and viral RNA genomes by APOBEC cytidine deaminases
5:30pm – 5:45pm Madhumita Sridharan, Indiana University Purdue University Indianapolis, Department of Biology. Interference of the Mismatch Repair Pathway with the DNA Replication Process
5:45pm – 6:00pm Hannah Daniels, University of Kentucky College of Medicine, Department of Toxicology and Cancer Biology. ABL1 Mediates MLH1 Regulation and Mismatch Repair

6:00pm – 8:00pm Dinner/informal poster viewing

7:30am – 8:30am Breakfast; Informal poster viewing

8:30am – 10:30am Session 4: DNA recombination proteins: structure and function

Discussion Leader: Maria Spies, University of Iowa.

8:30am – 9:30am Keynote talk: Eric Greene, Department of Biochemistry and Molecular Biophysics, Columbia University. Single molecule studies of Rad51 paralogs.
9:30am – 9:45am Eloise Dray, UT Health San Antonio, Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute San Antonio. The phosphorylation status of RAD51 controls its structure and function.
9:45am – 10:00am Sarah Hengel, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Pittsburgh. SWSAP1-SWS1 stimulates Rad51 D-loop formation on RPA-coated ssDNA.
10:00am – 10:15am Jaigeeth Deveryshetty, Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. CryoEM reveals how a recombination mediator catalyzes Rad51 filament formation.
10:15am – 10:30am Carola Neuman, Department of Pharmacology and Chemical Biology, University of Pittsburgh. Redox Regulation of RAD51 Cys319 and Homologous Recombination by Peroxiredoxin.

10:30am – 11:00am Coffee break; informal poster viewing

11:00am – 12:30am Session 5: DNA repair and disease

Discussion Leader: Todd Washington, University of Iowa.

11:00am – 11:15am Khaliunaa Bayanbold, University of Iowa. University of Iowa Hospitals and Clinics. Limiting iron availability promotes replication stress to enhance radio-chemosensitivity in non-small cell lung cancer.
11:15am – 11:30am Odjo Gouttia, University of Nebraska Medical Center, The MASTL-ENSA-PP2A/B55 Pathway Modulates Cisplatin Resistance in Oral Squamous Cell Carcinoma.
11:30am – 11:45am Sophie L. Granger, Department of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine. Human hnRNPA1 reorganizes telomere-bound Replication Protein A.
11:45am – 12:00pm Shivani Navalakha, Department of Biomedical Sciences, College of Medicine, University of Illinois-Chicago. Role of IP6 in a DNA double-stranded break Repair Pathway in Human Cells.
12:00am – 12:15pm Thomas E. Wilson, Department of Pathology, Department of Human Genetics University of Michigan. NHEJ-mediated chromosomal rearrangements in space and time: two species, two approaches.
12:15am – 12:30pm Marc Wold, Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa. Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases .

12:30pm – 1:00pm Closing remarks, prizes, selection of the next location

1:00pm Box lunches; departure